Spher4Sys: Systems biology based approach for preclinical lead compound development using an in-vivo like spheroid test system

The project is aiming towards a paradigm shift in cancer drug discovery and development, where the complex phenotype in cancer is the relevant target and read-out for the screening process, and not the single drugable target protein. Our goal is to generate and introduce clinical relevant phenotype information already early in the drug discovery and development process in order to reduce late substance failure and correlate chemical structures with clinical phenotypes.

Contact: Johannes Eichner, Raum C303, Tel. (07071) 29-70436, eichner at informatik.uni-tuebingen.de