Goal of this project is the development of efficient methods to optimize the kinetic parameters of metabolic pathway models. For this, problemspecific operators and algorithms have to be developed. Here, one main focus is on parallelization to reduce the computational complexity. The other crucial part is the separation of the problem into smaller subproblems in such a way that only a subset of parameters is optimized.

Optimization Algorithms

The new methods for the optimization of the kinetic model parameters are implemented in the existing framework JavaEvA that is developed in our research group.

Cooperations

Industry:

INSILICO biotechnology

Academic:

Prof. Dr.-Ing. Matthias Reuss, Institute for Biotechnologies, University of Stuttgart
Prof. Dr.-Ing. Oliver Kohlbacher, Simulation of Biological Systems , University of Tübingen